Research Article
Effect of Genetic and Laboratory Findings on Clinical Course of Antisynthetase Syndrome in a Hungarian Cohort
Table 3
Detailed comparison according to the stable dose of methylprednisolone.
| | Minimal stable steroid dose: (n=47) | 5.57mg±8.436 | | | <8mg | ≥8mg | p |
| | Number of patients: | 32 | 15 | - | | Male/Female: | 6/26 | 1/14 | 0.404 | | Mean age at disease onset ± SD (youngest-oldest): | 43.91±13.18(18-70) | 41.47±14.29(19-67) | - |
| | Clinical symptoms and laboratory parameters: |
| | myositis: | 32 | 100% | 15 | 100% | 1 | | LDH at diagnosis(U/l)±SD: | 1035.26±707.38 | 775.93±463.93 | 0.224 | | CK at diagnosis(U/l)±SD: | 3447.64±3176.22 | 2531.86±2982.12 | 0.374 | | ILD/alveolitis: | 24 | 75% | 11 | 73% | 1 | | arthritis: | 29 | 91% | 12 | 80% | 0.367 | | CRP at diagnosis(mg/l)±SD: | 17.84±18.32 | 36.34±25.39 | 0.014 | | ESR at diagnosis(mm/h)±SD: | 19.81±10.4 | 33.87±22.11 | 0.032 | | Raynaud-phenomenon: | 21 | 66% | 10 | 67% | 0.944 | | dysphagia: | 2 | 6% | 4 | 27% | 0.072 | | fever: | 11 | 34% | 10 | 67% | 0.038 | | Skin lesion: | 15 | 47% | 11 | 73% | 0.089 |
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SD: standard deviation; LDH: lactate dehydrogenase; CK: creatine kinase; ILD: interstitial lung disease; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate.
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