BioMed Research International

Research Article

Impact of Matrix Metalloproteinase 9 on COPD Development in Polish Patients: Genetic Polymorphism, Protein Level, and Their Relationship with Lung Function

Table 2

Alleles and genotypes distributions of -1562C/T SNP of MMP-9 gene (rs3918242) and copy number variability of MMP-9 gene in COPD patient and healthy control groups.


MMP-9 gene polymorphisms	Frequency (Number of positive)				p value
MMP-9 gene polymorphisms	COPD N=335/60	CTR N=309/61	CTR smokers N=110/23	CTR non-smokers N=199/38	p₁	p₂	p₃	p₄

rs3918242 (-1562 C/T)
Alleles
C	87.1 (583)	85.2 (526)	83.2 (183)	86.1 (343)	0.36	0.09	0.76	0.34
T	12.9 (87)	14.8 (92)	16.8 (37)	13.8 (55)	0.36	0.09	0.76	0.34
Genotypes
CC	76.2 (255)	73.2 (226)	69.1 (76)	75.3 (150)	0.61	0.34	0.36	0.43
CT	21.8 (73)	23.9 (74)	28.2 (31)	21.6 (43)
TT	2.0 (7)	2.9 (9)	2.7 (3)	10.9 (6)
CNV
1 copy	3.3 (2)	4.9 (3)	0.0 (0)	7.9 (3)	0.51	0.31	0.41	0.31
2 copies	85.0 (51)	82.0 (50)	91.3 (21)	76.3 (29)
3 copies	11.7 (7)	9.9 (6)	4.3 (1)	13.2 (5)
4 copies	0 (0)	3.2 (2)	4.3 (1)	2.6 (1)

N, number of individuals; COPD, chronic obstructive pulmonary disease groups; CTR, control group; , COPD patients versus CTR; , COPD patients versus CTR smokers; , COPD patients versus CTR nonsmokers; , CTR smokers versus CTR non-smokers; , CNV analyses were performed on 60 COPD patients and 61 controls (23 smokers and 38 nonsmokers).