Time Course of Cerebrovascular Reactivity in Patients Treated for Unruptured Intracranial Aneurysms: A One-Year Transcranial Doppler and Acetazolamide Follow-Up Study

Table 4

Regression results: difference in mean CVR between exams versus a number of variables.

	Simple		Multiple
	Estimate		Estimate
Age, years	0.1	0.68	0.8	0.03
Female	−4.9	0.42	−4.5	0.46
BMI, kg/m^2	−0.2	0.78	−0.1	0.84
Weight difference, kg	0.3	0.63	0.3	0.81
Hypertension	1.7	0.78	3.3	0.58
Smoking
Current	ref	-	ref	-
Previous	−2.8	0.67	−2.8	0.62
Never	−5.2	0.59	−0.7	0.94
Treatment modality
Coil	ref	-	ref	-
Clip	9.0	0.14	13.8	0.03
Maximum aneurysm diameter (Dmax)	3.2	0.005	2.5	0.04
Mean CVR at first exam, %	−0.3	0.04	−0.5	0.01
Difference in AZ dose per kg	−2.4	0.49	−1.9	0.81

AZ: acetazolamide; BMI: body mass index; CVR: cerebrovascular reactivity; Dmax: maximum diameter of the aneurysm dome (independent of angles and directions); ref: reference.