Time Course of Cerebrovascular Reactivity in Patients Treated for Unruptured Intracranial Aneurysms: A One-Year Transcranial Doppler and Acetazolamide Follow-Up Study
Table 4
Regression results: difference in mean CVR between exams versus a number of variables.
Simple
Multiple
Estimate
Estimate
Age, years
0.1
0.68
0.8
0.03
Female
−4.9
0.42
−4.5
0.46
BMI, kg/m2
−0.2
0.78
−0.1
0.84
Weight difference, kg
0.3
0.63
0.3
0.81
Hypertension
1.7
0.78
3.3
0.58
Smoking
Current
ref
-
ref
-
Previous
−2.8
0.67
−2.8
0.62
Never
−5.2
0.59
−0.7
0.94
Treatment modality
Coil
ref
-
ref
-
Clip
9.0
0.14
13.8
0.03
Maximum aneurysm diameter (Dmax)
3.2
0.005
2.5
0.04
Mean CVR at first exam, %
−0.3
0.04
−0.5
0.01
Difference in AZ dose per kg
−2.4
0.49
−1.9
0.81
AZ: acetazolamide; BMI: body mass index; CVR: cerebrovascular reactivity; Dmax: maximum diameter of the aneurysm dome (independent of angles and directions); ref: reference.