Simvastatin Effects on Inflammation and Platelet Activation Markers in Hypercholesterolemia
Table 2
Pro- and anti-inflammatory and oxidative stress markers in subjects at baseline and after two months of treatment with diet alone (control) or simvastatin.
Control (n=20)
Simvastatin (n=25)
Before
After
p value
Before
After
p value
Pro-inflammatory
IL-1b
0.98±0.63
0.94±0.46
0.5008
0.86±0.45
0.79±0.41
0.3625
IL-5
1.8±0.7
1.6±0.7
0.1043
2.0±1.7
2.2±1.4
0.1742
IL-6
6.7±2.5
6.7±2.4
0.6404
6.6±3.4
4.8±2.2
0.0034
IL-7
5.9±2.1
5.7±1.0
0.6676
5.6±2.5
4.9±1.9
0.2143
IL-8
16.8±4.3
15.6±4.0
0.1919
18.9±6.0
16.3±6.7
0.0447
IL-9
18.5±6.6
17.8±7.6
0.4428
17.7±11.6
19.0±15.2
0.6186
IL-12
22.8±7.3
21.4±6.8
0.5124
22.0±13
22.8±13
0.7145
IL-13
5.9±2.2
6.0±2.8
0.6864
7.3±4.3
4.5±2.7
<0.0001
IFN-
32.7±14.4
34.0±16.2
0.6744
38.1±13.6
18.3±7.5
<0.0001
IP-10
519±226
476±195
0.1960
491±219
521±264
0.6189
Eotaxin
177±63
177±46
0.7509
143±67
167±54
0.0534
MCP-1
57±23
60±16
0.5257
60±45
50±31
0.1906
Anti-Inflammatory
IL-10
1.07±0.55
1.04±0.51
0.7046
1.03±0.56
2.10±0.51
<0.0001
sRAGE
678±268
659±248
0.4637
740±263
1147±310
<0.0001
Oxidative Stress
8-OH-dG
1.60±0.56
1.62±0.58
0.9038
1.84±0.59
1.33±0.56
<0.0001
Data are presented as mean ± SD. IL, interleukin; MCP, Monocyte Chemoattractant Protein; sRAGE, Soluble Receptor of Advanced Glycation End Products; 8-OH-dG, 8-hydroxy-2’-deoxyguanosine. Concentrations are expressed as pg/ml, except where otherwise indicated. For p value, paired Student’s t-test or Wilcoxon test was used as appropriate.
