Simvastatin Effects on Inflammation and Platelet Activation Markers in Hypercholesterolemia

Table 3

Correlation between LDL-C and pro- and anti-inflammatory, oxidative stress, and platelet activation markers in hypercholesterolemic patients at baseline.

	LDL-C
	r	p
IFN-	0.493	0.001
IL-6	0.427	0.003
VEGF	0.301	0.044
E-Selectin	0.560	<0.0001
sCD-40L	0.348	0.019
IL-10	-0.364	0.014
sRAGE	-0.484	0.001
8-OH-dG	0.307	0.040
MA ADP	0.638	<0.0001
MA COLL	0.614	<0.0001
MA AA	0.623	<0.0001
IC-50 L-ASA	0.600	<0.0001

IFN, interferon; IL, interleukin; VEGF, vascular endothelial growth factor; sCD-40L, soluble CD-40 ligand; IL, interleukin; sRAGE, Soluble Receptor of Advanced Glycation End Products; 8-OH-dG, 8-hydroxy-2’-deoxyguanosine; MA, maximal aggregation; Coll, collagen; AA, arachidonic acid; IC-50, half-maximal inhibitory concentration; L-ASA, lysine acetylsalicylate.