Simvastatin Effects on Inflammation and Platelet Activation Markers in Hypercholesterolemia

Table 4

Correlation between platelet function, expressed as maximal aggregation (MA) to ADP (a), collagen (b), AA, and L-ASA IC-50 (d), and pro- and anti-inflammatory, oxidative stress, and platelet activation markers in hypercholesterolemic patients at baseline.

(a) MA to ADP

	r	p
IFN-	0.391	0.008
IL-6	0.384	0.009
VEGF	0.326	0.029
P-Selectin	0.326	0.029
E-Selectin	0.432	0.003
sRAGE	-0.453	0.002

(b) MA to collagen

	r	p
IFN-	0.326	0.029
IL-6	0.327	0.028
PDGF-BB	0.331	0.027
E-Selectin	0.419	0.004

(c) MA to AA

	r	p
IFN-	0.315	0.035
IL-10	-0.448	0.002
IL-1b	0.320	0.032
IL-6	0.425	0.004
E-Selectin	0.515	0.0003
sCD-40L	0.562	<0.0001
sRAGE	-0.515	0.0003

(d) L-ASA IC-50 to AA

	r	p
IL-6	0.347	0.020
E-Selectin	0.339	0.023
sCD-40L	0.442	0.002
sRAGE	-0.454	0.002

TC, total cholesterol; LDL-C, low-density lipoprotein; IFN, interferon; IL, interleukin; VEGF, vascular endothelial growth factor; sCD-40L, soluble CD-40 ligand; IL, interleukin; sRAGE, Soluble Receptor of Advanced Glycation End Products; PDGF, Platelet Derived Growth Factor; Coll, collagen; AA, arachidonic acid; IC-50, half-maximal inhibitory concentration; L-ASA, lysine acetylsalicylate.