Simvastatin Effects on Inflammation and Platelet Activation Markers in Hypercholesterolemia

Table 5

Multivariate regression analysis between baseline platelet function values, expressed as maximal aggregation (MA) to ADP (a), collagen (b), AA, and L-ASA IC-50 (d), entered as dependent variable, and markers of lipid control, inflammation, endothelial dysfunction, oxidative stress, and platelet activation markers, entered as independent variables. The table shows the final regression parameters after a backward selection algorithm in which all variables were present in the first step.

(a) MA to ADP

MA to ADP	Adjusted R^2=0.362	F=25.954	p<0.0001
	Constant	B=7.072	p=0.7299
	LDL-C	B=0.250	p=0.0016
	VEGF	B=0.191	p=0.0081
	p-Selectin	B=0.134	p=0.0009
	sRAGE	B=-0.021	p=0.0510

(b) MA to collagen

MA to Collagen	Adjusted R^2=0.393	F=15.239	p<0.0001
	Constant	B=31.722	p=0.0069
	LDL-C	B=0.290	p<0.0001

(c) MA to AA

MA to AA	Adjusted R^2=0.615	F=18.580	p<0.0001
	Constant	B=21.873	p=0.0946
	LDL-C	B=0.211	p=0.0003
	IL-10	B=-8.762	p=0.0240
	IL-1b	B=9.012	p=0.0128
	sCD-40L	B=1.549	p=0.0013

(d) L-ASA IC-50 to AA

L-ASA IC-50 to AA	Adjusted R^2=0.394	F=15.302	p<0.0001
	Constant	B=1.406	p=0.8282
	LDL-C	B=0.132	p=0.0002
	sCD-40L	B=0.609	p=0.0398