Pharmacokinetic Interaction Study of Ketamine and Rhynchophylline in Rat Plasma by Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry

Table 3

Primary pharmacokinetic parameters after intraperitoneal administration of ketamine in rats (n = 6).

Parameters	Unit	Ketamine	Ketamine + rhynchophylline
	ng/mLh	1080.4± 156.6	4085.7 ± 2784.8
	ng/mLh	1083.4 ± 158.7	4086.7 ± 2784.3
	h	1.4 ± 0.3	1.0 ± 0.3
	h	1.4 ± 0.3	1.1 ± 0.3
t1/2	h	5.4 ± 2.6	2.4 ± 1.5
CL	L/h/kg	28.1 ± 3.7	10.4 ± 5.6
V	L/kg	208.1 ± 84.3	35.2 ± 28.3
	ng/mL	779.5 ± 212.6	3275.7 ± 2357.1

Compared to ketamine group, , .