Research Article
Pharmacokinetic Interaction Study of Ketamine and Rhynchophylline in Rat Plasma by Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry
Table 3
Primary pharmacokinetic parameters after intraperitoneal administration of ketamine in rats (n = 6).
| Parameters | Unit | Ketamine | Ketamine + rhynchophylline |
| | ng/mLh | 1080.4± 156.6 | 4085.7 ± 2784.8 | | ng/mLh | 1083.4 ± 158.7 | 4086.7 ± 2784.3 | | h | 1.4 ± 0.3 | 1.0 ± 0.3 | | h | 1.4 ± 0.3 | 1.1 ± 0.3 | t1/2 | h | 5.4 ± 2.6 | 2.4 ± 1.5 | CL | L/h/kg | 28.1 ± 3.7 | 10.4 ± 5.6 | V | L/kg | 208.1 ± 84.3 | 35.2 ± 28.3 | | ng/mL | 779.5 ± 212.6 | 3275.7 ± 2357.1 |
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Compared to ketamine group, , . |