Prospects of Noncoding RNAs in Hepatocellular Carcinoma

Table 1

The function of abnormal expression miRNAs in HCC and in the serum of HCC patients.

miRNAs	Target gene	Function	References
miR-224	HOXD10	Promoting the invasion and metastasis of cancer cells	[43]
miR-224	SMAD4	Promoting cell proliferation	[44]
miR-224	ppp2r1b	Increasing the risk of liver cancer	[45]
miR-221	p27 and p57	Promoting the progression of hepatocellular carcinoma cell cycle	[46, 47]
miR-221	DDIT4	Promoting tumor development	[48]
miR-221	SOCS1 and SOCS3	Enhancing the effectiveness of interferon against HCV	[50]
miR-21	map2k3	Promoting the proliferation of cancer cells	[51]
miR-21	PDCD4	Increased the risk of liver cancer invasion and metastasis	[52]