Gene Expression Profile Signature of Aggressive Waldenström Macroglobulinemia with Chromosome 6q Deletion

Figure 1

FISH analysis of BM aspirates using the A20/BLIMP1/SHGC-79576 Three Color Probe (Cancer Genetics Italia™) and IL21R staining of a BM biopsied specimen. Green, red, and yellow signals represent BLIMP1, A20, and SHGC-79576, respectively. (a) 6q del pattern. One green, one red, and two yellow signals were detected, showing nuc ish(SHGC-79576 x2, BLIMP-1x1, A20 x1). (b) Normal pattern. Two green, two red, and two yellow signals are recognized, showing nuc ish (SHGC-79576, BLIMP-1, A20) x2. (c) >70% positivity of IL-21R in lymphoplasmacytic cells and plasma cells (original magnification ×600). (d) <30% positivity of IL-21R in lymphoplasmacytic cells and plasma cells (original magnification ×600).

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