Research Article
Gene Expression Profile Signature of Aggressive Waldenström Macroglobulinemia with Chromosome 6q Deletion
| | | all (N=8) | 6q del (+) (N=3) | 6q del (-) (N=5) |
| | Median Age (old, range) | 71.5 (58-79) | 76 (70-79) | 71 (58-76) |
| | Sex (M/F) (%) | 5/3 | 2/1 | 3/2 |
| | PS>1 (%) | 5 | 2 | 3 |
| | Hb <11.5 g/dL (%) | 6 | 3 | 3 |
| | plt <10×109/L (%) | 1 | 0 | 1 |
| | β2MG>3mg/L (%) | 3 (64.3) | 2 | 2 |
| | Median M-protein (g/dL) | 2.65 (0.8-4.28) | 3.14 (2.13-4.28) | 2.25 (0.8-3.87) |
| | ISSWM(Low/Int/High) (%) | 0/4/4 (9/36/55) | 0/1/2 | 0/3/2 |
| | B-symptom (%) | 2 (29.4) | 1 | 1 |
| | Hepatomegaly (%) | 1 (23.8) | 0 | 1 |
| | Splenomegaly (%) | 1 (23.8) | 0 | 1 |
| | Lymphadenopathy (%) | 2(25) | 0 | 2 |
| | Cold agglutinin disease | 2 | 0 | 2 |
| | Infiltration pattern (D/P) | 7/1 | 3/0 | 4/1 |
| | Plasma cell (%) | 1.9 (1-3.6) | 2.0 (1-2.2) | 1.8 (1.2-3.6) |
| | Lymphoplasmacytic cell (%) | 3.3 (2.4-8.6) | 7.1 (2.6-8.6) | 3.0 (2.4-5.2) |
| | Small lymphocyte (%) | 39.0 (29.4-62.8) | 41.6 (35.9-62.8) | 36.4 (29.4-46.8) |
| | Total neoplastic cell (%) | 45.7 (36-72.4) | 46.4 (45-72.4) | 41.4 (36-50.4) |
|
|
PS: performance status; Hb: hemoglobin; plt: platelets; β2MG: β2-microglobulin; cCa: calculated Ca; ISSWM: International Prognostic Scoring System for Waldenström Macroglobulinemia.
|
