Effective Treatment of Chronic Proliferative Cholangitis by Local Gentamicin Infusion in Rabbits

Figure 3

Changes in inflammatory factors in the common bile duct wall and stones. Cox-2 protein expression in the AT group was slightly decreased by gentamicin treatment comparing with the positive control group (a), but still significantly higher than that in the sham-operation group after semiquantified assessment (b) (sham-operation versus antibiotic treatment group, p<0.001). The concentration of IL-2 in the bile duct in the antibiotic treatment group was inhibited by gentamicin to almost normal (sham-operation versus antibiotic treatment group, p>0.05), which was significantly lower than that in the positive control group (antibiotic treatment versus positive control group, p<0.001) (c). The same tendency was observed in the endogenous beta-glucuronidase activity (d).

(a)

(b)

(c)

(d)