Self-Nanoemulsifying Drug Delivery System of Tetrandrine for Improved Bioavailability: Physicochemical Characterization and Pharmacokinetic Study

Table 1

Result of solubility studies with Tet in various excipients (n=3).

Sample	Excipient	Function in SNEDDS	Solubility(mg/mL)
1	Oleic acid	Oil	8.674±0.056
2	Soybean oil	Oil	2.372±0.091
3	Isopropyl acetate	Oil	2.291±0.117
4	Olive oil	Oil	2.124±0.065
5	Ethyl linoleate	Oil	3.326±0.177
6	Isopropyl myristate (IPM)	Oil	4.348±0.198
7	Ethyl oleate	Oil	1.185±0.066
8	Butyl oleate	Oil	1.194±0.064
9	Tween-60	Surfactant	4.216±0.208
10	Tween-80	Surfactant	6.793±0.324
11	SPC	Surfactant	10.238±0.199
12	Cremophor RH-40	Surfactant	12.645±0.252
13	Isopropanol	Co-surfactant	2.564±0.088
14	Glycerol	Co-surfactant	3.455±0.100
15	PEG400	Co-surfactant	9.584±0.225
16	Absolute alcohol	Co-surfactant	8.449±0.165