Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression

Table 1

Processes involved in hepatocarcinogenesis and associated microRNAs.

Processes	target	microRNAs
Cell cycle and apoptosis	Cyclin D	miR-199a/b-3p, miR-19a, miR-451, miR-138, miR-302b
	p53	miR-1228, miR-221, miR-1228
	PTEN	miR-148a, miR-93, miR-216a/217, miR-21
	SOX7	miR-184, miR-24
	c-myc	miR-451, miR-148a-5p, miR-363-3p
	AKT	miR-133a, miR-105, miR-331-3p
	Bcl-2	miR-125b, miR-224, miR-200
Invasion and metastasis	SMAD	miR-125b, miR-224
	Beta-catenin	miR-200a
	MMP-2	miR-29b
	PIK3	miR-126-3p, miR-7
angiogenesis	VEGF	miR-195, miR-146a
	VEGFA	miR-302c, miR-26a
	AEG-1	miR-375, miR-302c

PTEN, phosphatase and tensin homolog; SOX7, SRY-related HMG-box; MMP-2, matrix metalloproteases 2; VEGF, vascular endothelial growth factor; and AEG-1, astrocyte elevated gene-1.