Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression

Table 3

Aberrant miRNAs associated with invasion and metastasis.

MicroRNAs	Type of deregulation	Target	Reference
miR-200	Upregulated	VASH2 CDC42, CDH1, PAK2, BCL-2	[46, 47]
miR-224	Downregulated	CDC42, CDH1, PAK2, BCL-2	[48]
miR-122	Downregulated	KLF6	[49]
miR-200a	Upregulated	Beta-catenin	[50]
miR-329	Upregulated	BRD4	[51]
miR-362-5p	Upregulated	CYLD	[52]
miR-93	Upregulated	PTEN, CDKN1A	[40]
miR-216a/217	Upregulated	PTEM, SMAP7	[53, 54]
miR-221	Upregulated	HDAC6	[55]
miR-657	Upregulated	TLE1	[56]
miR-195	Downregulated	IKK alpha, TAB3	[57]
miR-331-3p	Upregulated	AKT	[58]
miR-7	Downregulated	PIK3CD	[59, 60]