Inhibitor of Differentiation-3 and Estrogenic Endocrine Disruptors: Implications for Susceptibility to Obesity and Metabolic Disorders

Figure 3

ID3 mediated inhibition of adiponectin contributes to excess adipocytes. Low circulating levels of adiponectin have been linked to several components of the metabolic syndrome. The figure illustrates how EEDs may lead to decrease in adiponectin levels via ID3 redox signaling. Elevated levels of ID3 protein bind to E47, which further prevent cobinding with SREBP-1C and may result in blocking the transcription of adiponectin gene. Additionally ID3 demonstrates regulation of MCP-1 causing increase in inflammation and adipocyte proliferation.