Inhibitor of Differentiation-3 and Estrogenic Endocrine Disruptors: Implications for Susceptibility to Obesity and Metabolic Disorders

Table 3

Summary of pathways involved in the 18 common genes related to ID3, MetS, and EEDs.

Pathway ID	Pathway description	Matching proteins in your network (labels)
GO.0001944	Vasculature development	APOE, BMPR2, ID1, IGF1, MFGE8, MMP14, NKX2-5, THBS1, VEGFA
GO.0072358	Cardiovascular system development	APOE, BMPR2, ID1, ID3, IGF1, MFGE8, MMP14, NKX2-5, THBS1, VEGFA
GO.0072359	Circulatory system development	APOE, BMPR2, ID1, ID3, IGF1, MFGE8, MMP14, NKX2-5, THBS1, VEGFA
GO.0001568	Blood vessel development	APOE, BMPR2, ID1, MFGE8, MMP14, NKX2-5, THBS1, VEGFA
GO.0030324	Lung development	BMPR2, ID1, IGF1, MMP14, SREBF1, VEGFA
GO.0048514	Blood vessel morphogenesis	APOE, ID1, MFGE8, MMP14, NKX2-5, THBS1, VEGFA
GO.0010941	Regulation of cell death	APOE, ATF3, ID1, ID3, IGF1, MDK, MMP3, NKX2-5, THBS1, VEGFA
GO.0050678	Regulation of epithelial cell proliferation	APOE, BMPR2, ID1, IGF1, THBS1, VEGFA
GO.0048511	Rhythmic process	ID1, ID3, ID4, MMP14, SREBF1, VEGFA
GO.0030334	Regulation of cell migration	APOE, BMPR2, IGF1, MMP14, MMP3, THBS1, VEGFA
GO.0001525	Angiogenesis	ID1, MFGE8, MMP14, THBS1, VEGFA
GO.0007623	Circadian rhythm	ID1, ID3, ID4, SREBF1
GO.0006979	Response to oxidative stress	APOE, GPX3, MMP14, MMP3, THBS1
GO.0000302	Response to reactive oxygen species	APOE, GPX3, MMP3, THBS1
GO.0031325	Positive regulation of cellular metabolic process	APOE, ATF3, BMPR2, ID4, IGF1, MDK, MMP14, NKX2-5, THBS1, VEGFA
GO.0048545	Response to steroid hormone	MDK, MFGE8, MMP14, SREBF1, THBS1
GO.0031324	Negative regulation of cellular metabolic process	APOE, BMPR2, ID1, IGF1, MMP3, NKX2-5, SREBF1, THBS1, VEGFA
GO.0045540	Regulation of cholesterol biosynthetic process	APOE, SREBF1
GO.0006950	Response to stress	APOE, BMPR2, GPX3, ID3, IGF1, MMP14, MMP3, SREBF1, THBS1, VEGFA
GO.0001935	Endothelial cell proliferation	BMPR2, MMP14
GO.0008283	Cell proliferation	BMPR2, ID4, IGF1, MMP14, NKX2-5
GO.0043536	Positive regulation of blood vessel endothelial cell migration	THBS1, VEGFA
GO.0034645	Cellular macromolecule biosynthetic process	APOE, ATF3, BMPR2, ID1, ID3, ID4, IGF1, SREBF1, ST6GAL1, THBS1
GO.0051781	Positive regulation of cell division	IGF1, MDK, VEGFA
GO.0009101	Glycoprotein biosynthetic process	BMPR2, IGF1, ST6GAL1, THBS1
GO.0008361	Regulation of cell size	APOE, BMPR2, VEGFA
GO.0043534	Blood vessel endothelial cell migration	ID1, VEGFA
GO.0016477	Cell migration	ID1, MDK, MMP14, THBS1, VEGFA
GO.0032369	Negative regulation of lipid transport	APOE, THBS1
GO.0048568	Embryonic organ development	ID3, MMP14, NKX2-5, VEGFA
GO.0045765	Regulation of angiogenesis	ID1, THBS1, VEGFA
GO.0051172	Negative regulation of nitrogen compound metabolic process	APOE, BMPR2, ID1, NKX2-5, SREBF1, VEGFA
GO.0007166	Cell surface receptor signaling pathway	BMPR2, ID1, IGF1, MDK, NKX2-5, SREBF1, VEGFA
GO.0032269	Negative regulation of cellular protein metabolic process	APOE, ATF3, IGF1, THBS1, VEGFA
GO.0045937	Positive regulation of phosphate metabolic process	APOE, BMPR2, IGF1, THBS1, VEGFA
GO.0051148	Negative regulation of muscle cell differentiation	ID3, NKX2-5
GO.0030155	Regulation of cell adhesion	IGF1, MMP14, THBS1, VEGFA