Association of Androgen Excess with Glucose Intolerance in Women with Polycystic Ovary Syndrome
Table 1
Characteristics of subjects based on different glucose tolerance status.
NGT
Prediabetes
T2DM
226
119
33
-
Age,
29.0 ± 4.
28.5 ± 4.4
0.001
Oligomenorrhea, %
167 (73.9)
79 (66.4)
25 (75.8)
0.259
Hyperandrogenism, %
145 (64.2)
72 (60.5)
21 (63.6)
0.834
Polycystic ovaries, %
190 (84.1)
97 (81.5)
29 (87.9)
0.717
BMI, kg/m2
29.3 ± 5.5
30.6 ± 4.
31.5 ± 4.
0.012
Waist circumference, cm
90.6 ± 14.4
96.1 ± 12.
97.2 ± 8.
0.014
Waist-to-hip ratio
0.88 ± 0.08
0.91 ± 0.0
0.92 ± 0.0
0.014
Systolic BP, mmHg
120.3 ± 13.7
125.4 ± 14.
134.6 ± 17.
<0.001
Diastolic BP, mmHg
78.7 ± 11.7
83.5 ± 12.
91.3 ± 13.
<0.001
Hypertension, %
32 (14.2)
32
15
<0.001
Fasting glucose, mmol/L
4.9 ± 0.4
5.4 ± 0.
6.4 ± 1.
<0.001
Fasting insulin, uIU/mL
<0.001
Family history of diabetes, %
36 (15.9)
33 (27.7)
6 (18.2)
0.056
Triglycerides, mmol/L
1.5 (1.1–2.2)
1.7
1.8 (1.4–2.4)
0.028
Total cholesterol, mmol/L
4.7 ± 0.9
4.8 ± 1.1
4.7 ± 0.7
0.801
HDL-cholesterol, mmol/L
1.2 ± 0.3
1.1 ± 0.5
1.0 ± 0.2
0.296
LDL-cholesterol, mmol/L
2.7 ± 0.7
2.7 ± 0.9
2.8 ± 0.7
0.659
Testosterone, nmol/L
1.0 (0.7–1.5)
1.1 (0.7–1.6)
1.4
0.033
DHEAS, ug/dL
235.9 ± 109.0
235.9 ± 104.9
216.6 ± 106.4
0.672
SHBG, nmol/L
18.2 (11.2–26.9)
0.028
FAI
5.0 (2.8–7.6)
6.2
7.9
<0.001
NGT, normal glucose tolerance; T2DM, type 2 diabetes mellitus; BMI, body mass index; BP, blood pressure; DHEAS, sulfated dehydroepiandrosterone; SHBG, sex hormone-binding globulin; FAI, free androgen index. Data are presented as mean ± SD, median (25th–75th interquartile range), or (%). versus NGT group; versus prediabetes group.
