iTRAQ-Based Proteomics Analysis Reveals the Effect of Rhubarb in Rats with Ischemic Stroke

Table 1

Quantitative information of the overlapping DEPs in RG versus MG.

No.	Uniprot Accession	Gene name	Unused	Cov	Protein identity	Peptides	AVG.
				(95)
						(95%)
1	G3V7C6	Tubb4b	2	76.64	Tubulin beta-4B chain	274	2.43
2	Q9WTY2	Rem2	2.04	4.98	GTP-binding protein REM 2	2	1.88
3	Q04940	Nrgn	4.01	46.15	Neurogranin	7	3.81
4	P10818	Cox6a1	4.08	27.93	Cytochrome c oxidase subunit 6A1, mitochondrial	3	2.21
5	P04094	Penk	4.1	11.15	Proenkephalin-A	3	1.70
6	P22057	Ptgds	4.23	29.63	Prostaglandin-H2 D-isomerase	6	1.76
7	P35332	Hpcal4	6.4	49.21	Hippocalcin-like protein 4	12	2.15
8	P60841	Ensa	7.12	47.11	Alpha-endosulfine	7	2.99
9	Q3ZAV2	Ybx1	7.86	27.30	Nuclease-sensitive element-binding protein 1	4	1.60
10	G3V997	Dcx	8.55	20.82	Neuronal migration protein doublecortin	9	1.80
11	Q6AXS4	Atp6ap2	9.02	16.00	Renin receptor	8	1.73
12	P37377	Snca	9.85	80.71	Alpha-synuclein	22	2.37
13	O35796	C1qbp	10.07	28.32	Complement component 1 Q subcomponent-binding protein, mitochondrial	8	1.63
14	B7X6I3	Cend1	10.49	56.38	C38 protein	19	2.00
15	F8WFH6	Fam131b	11.76	20.28	Protein FAM131B	7	1.89
16	Q5U2U8	Bag3	12	17.42	Bcl2-associated athanogene 3	9	1.60
17	P35213	Ywhab	12.04	78.46	14-3-3 protein beta/alpha	65	1.92
18	O70257	Stx7	12.21	39.85	Syntaxin-7	13	3.47
19	A0A0G2K0M8	Ncam1	12.94	50.30	Neural cell adhesion molecule 1	77	2.44
20	P07825	Syp	13.95	40.07	Synaptophysin	19	1.55
21	P07171	Calb1	16.2	41.38	Calbindin	16	1.51
22	D3ZUX5	Chchd3	16.88	35.68	MICOS complex subunit	13	3.34
23	P62982	Rps27a	17.28	54.49	Ubiquitin-40S ribosomal protein S27a	23	1.62
24	D4A0T0	Ndufb10	18.05	61.93	Protein Ndufb10	15	2.43
25	Q09073	Slc25a5	18.08	61.07	ADP/ATP translocase 2	46	2.03
26	A0A0H2UHV6	Ppp3r1	18.44	61.25	Calcineurin subunit B type 1	17	1.55
27	D4A5L9	LOC679794	18.53	71.43	Protein LOC679794	24	3.31
28	P61589	Rhoa	19.6	64.77	Transforming protein RhoA	24	2.52
29	F1M378	Unc13a	20.94	6.01	Protein unc-13 homolog A	11	4.26
30	O88767	Park7	21.87	91.53	Protein deglycase DJ-1	22	1.76
31	D4AA63	Ubqln2	24.33	27.12	Protein Ubqln2	22	1.53
32	P14604	Echs1	24.5	53.45	Enoyl-CoA hydratase, mitochondrial	20	2.09
33	P08461	Dlat	27.5	35.60	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	25	3.38
34	P63086	Mapk1	31.61	49.16	Mitogen-activated protein kinase 1	26	1.63
35	Q6P6R2	Dld	33.08	54.03	Dihydrolipoyl dehydrogenase, mitochondrial	31	1.98
36	Q05175	Basp1	34.26	86.82	Brain acid soluble protein 1	82	4.18
37	P62161	Calm1	34.4	89.93	Calmodulin	80	2.64
38	P11275	Camk2a	35.04	64.44	Calcium/calmodulin-dependent protein kinase type II subunit alpha	76	1.73
39	P35565	Canx	35.34	37.39	Calnexin	31	1.50
40	P07936	Gap43	37.7	84.51	Neuromodulin	48	3.07
41	Q9Z0W5	Pacsin1	38.67	56.46	Protein kinase C and casein kinase substrate in neurons protein 1	50	1.61
42	P21707	Syt1	40.02	45.61	Synaptotagmin-1	37	1.79
43	Q5RKI0	Wdr1	42.43	46.37	WD repeat-containing protein 1	33	1.53
44	P63102	Ywhaz	43.94	85.31	14-3-3 protein zeta/delta	77	1.90
45	P06761	Hspa5	57.41	55.20	78 kDa glucose-regulated protein	57	1.55
46	P05708	Hk1	76.09	47.17	Hexokinase-1	80	1.50
47	Q63198	Cntn1	77.28	48.29	Contactin-1	77	1.74
48	D3ZMI4	Epb41l1	82.1	34.24	Band 4.1-like protein 1	52	1.77
49	P09951	Syn1	91.64	72.30	Synapsin-1	152	2.34
50	F1LQ81	Nsf	104.81	69.22	N-ethylmaleimide sensitive fusion protein, isoform CRA_b	86	1.84
51	D3ZQQ5	Dnm1	112.88	68.06	Dynamin-1	107	1.52
52	G3V984	Bsn	155.27	32.42	Protein bassoon	111	1.53
53	F1M779	Cltc	171.28	58.69	Clathrin heavy chain	213	1.76
54	A0A0G2K839	Clcn5	2	4.41	Chloride channel protein	3	0.02
55	G3V8L6	Kcna6	2.13	6.04	Potassium voltage-gated channel subfamily A member 6	2	0.65
56	D3ZV91	L3hypdh	4	7.34	Protein L3hypdh	2	0.48
57	F1LSV4	Sptlc2	4	5.18	Protein Sptlc2	3	0.52
58	A0A0G2K1A2	Mpo	4.01	3.76	Protein Mpo	3	0.65
59	P28572	Slc6a9	4.94	8.62	Sodium- and chloride-dependent glycine transporter 1	5	0.60
60	P55009	Aif1	5.28	23.13	Allograft inflammatory factor 1	5	0.60
61	Q6AYR8	Scrn2	5.8	13.00	Secernin-2	6	0.43
62	A0A0G2JWX4	Krt2	6.06	9.36	Keratin, type II cytoskeletal 2 epidermal	4	0.45
63	G3V6M3	Syt2	6.27	29.38	Synaptotagmin II	17	0.48
64	Q9R0I8	Pip4k2a	7.18	22.66	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	14	0.46
65	Q7TP91	Surf4	10	9.55	Ab1-205	9	0.55
66	P0DMW1	Hspa1b	16.76	41.34	Heat shock 70 kDa protein 1B	73	0.51
67	P60203	Plp1	17.43	31.41	Myelin proteolipid protein	50	0.20
68	Q63345	Mog	18.16	36.73	Myelin-oligodendrocyte glycoprotein	14	0.39
69	A0A0G2JWM2	Sirt2	31.35	52.32	NAD-dependent protein deacetylase sirtuin-2	34	0.61
70	Q63357	Myo1d	31.36	21.27	Unconventional myosin-Id	27	0.48
71	E9PTX9	Slc12a2	34.28	21.28	Protein Slc12a2	26	0.44
72	P02688	Mbp	35.6	66.67	Myelin basic protein	88	0.23
73	F1LRZ7	Nefh	54.4	41.26	Neurofilament heavy polypeptide	55	0.47
74	P19527	Nefl	55.56	58.49	Neurofilament light polypeptide	87	0.32
75	P13233	Cnp	62.44	74.52	2′,3′-cyclic-nucleotide 3′-phosphodiesterase	83	0.47
76	P12839	Nefm	79.88	49.88	Neurofilament medium polypeptide	86	0.49