Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling

Figure 2

Cyclin G2 inhibits the expression of proteins associated with glomerulosclerosis via canonical Wnt signalling. (a) Representative western blots and (b) densitometry for β-catenin, p-β-catenin, GSK3β, p-GSK3β, cyclin D1, MMP7, FN, and collagen IV in cyclin G2-overexpressing HMC cells (LV-CCNG2) treated with 5 μM CHIR99021 or DMSO (control group) for 72 h. Values are presented as the mean ± SD (n = 3); < 0.05, < 0.01, n.s.: not significant.

(a)

(b)