Mechanism of Azalomycin F<sub>5a</sub> against Methicillin-Resistant<i> Staphylococcus aureus</i>

<div><i>Adenylate kinase activities of MRSA cultures treated with different concentrations of azalomycin </i><span class="nowrap"><svg height="11.7919pt" id="M58" style="vertical-align:-3.286489pt" version="1.1" viewbox="-0.0498162 -8.50541 16.1518 11.7919" width="16.1518pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M132 649L125 622C205 614 209 611 192 523L116 125C100 40 92 34 17 27L11 0H274L281 27C190 34 182 41 198 125L232 308H336C422 308 424 300 424 227H452L490 419H462C435 354 431 347 345 347H240L284 576C291 610 293 615 327 615H408C480 615 497 605 505 580C513 560 515 526 516 494L545 496C552 554 561 631 563 649H132Z" id="g189-71"></path></g><g transform="matrix(.0091,0,0,-0.0091,6.877,3.132)"><path d="M459 623H177L96 330L102 324C115 328 154 340 193 340C293 340 332 281 332 202C332 93 272 37 190 37C128 37 87 70 63 96C55 103 50 103 42 98C28 91 18 77 16 65C14 52 19 41 31 28C49 9 93 -12 140 -12C184 -12 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46 355 46 340C46 316 72 295 91 295C106 295 117 303 122 319C131 350 139 371 152 384C163 397 178 404 197 404C246 404 281 365 281 293V278C260 262 186 232 124 213C69 194 41 161 41 112C41 47 92 -12 163 -12C195 -12 243 25 283 51C288 35 293 22 308 7C319 -4 339 -12 354 -12L442 39ZM281 87C262 68 226 51 199 51C169 51 129 74 129 126C129 162 151 181 190 198C211 208 259 229 281 240V87Z" id="g58-95"></path></g></svg>,</span> were incubated at 37°C for 6 h, and their luminescence <svg height="11.5564pt" id="M60" style="vertical-align:-2.26807pt" version="1.1" viewbox="-0.0498162 -9.28833 36.8666 11.5564" width="36.8666pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M300 -147C201 -63 143 98 143 270S200 602 300 686L282 710C136 610 70 450 70 271V270C70 89 136 -72 282 -170L300 -147Z" id="g113-41"></path></g><g transform="matrix(.013,0,0,-0.013,4.498,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 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174 271 146 252 97C262 78 278 59 294 51C309 59 326 78 336 97C317 146 311 174 308 231C356 200 377 181 410 140C431 139 456 143 471 153Z" id="g113-43"></path></g></svg> indicates a significant difference between blank control and azalomycin <svg height="11.6836pt" id="M62" style="vertical-align:-3.29562pt" version="1.1" viewbox="-0.0498162 -8.38798 16.0501 11.6836" width="16.0501pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M493 503C489 551 484 614 483 650H43V622C120 616 128 611 128 525V126C128 40 120 34 40 28V0H312V28C221 34 213 40 213 126V307H316C407 307 412 296 424 227H453V420H424C412 355 407 346 316 346H213V584C213 613 216 616 246 616H322C398 616 419 607 436 579C449 559 455 539 464 499L493 503Z" id="g121-68"></path></g><g transform="matrix(.0091,0,0,-0.0091,6.877,3.132)"><path d="M158 548H390L417 615L410 623H122L83 318C105 326 143 337 185 337C296 337 350 275 350 188C350 116 308 42 225 42C164 42 122 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BioMed Research International

fig3

Figure 3

Figure 3: Mechanism of Azalomycin F<sub>5a</sub> against Methicillin-Resistant<i> Staphylococcus aureus</i> 

BioMed Research International

Mechanism of Azalomycin F5a against Methicillin-Resistant Staphylococcus aureus

Figure 3

Mechanism of Azalomycin F_5a against Methicillin-Resistant Staphylococcus aureus