Review Article

Impact of Early versus Late Initiation of Renal Replacement Therapy in Patients with Cardiac Surgery-Associated Acute Kidney Injury: Meta-Analysis with Trial Sequential Analysis of Randomized Controlled Trials

Figure 5

Random-effects meta-regression analysis showing the relationship between the relative risk and publication year. The size of the circles is inversely proportional to the size of the result study variance, so that more precise studies have larger circles.