Impact of Early versus Late Initiation of Renal Replacement Therapy in Patients with Cardiac Surgery-Associated Acute Kidney Injury: Meta-Analysis with Trial Sequential Analysis of Randomized Controlled Trials

Table 2

Definition of early and late RRT in studies included in the meta-analysis.

Reference (year)	KDIGO criteria	Early RRT	Late RRT
Durmaz 2003 [10]	KDIGO 1	Serum Cr rise >10% from pre-op; level within 48 h of surgery	Serum Cr rise >50% from pre-op level; or UOP <400 mL over 24 h of surgery
Sugahara 2004 [11]	KDIGO 2	Within 12 h of UOP <30 mL/h or urine output <750 ml/day	After 12 h of UOP <20 mL/h or; urine output <500 ml/day
Crescenzi 2015 [12]	KDIGO 1	Within 12 h of UOP <0.5 mL/kg/h	After 12 h on the basis of persistent; (>6 h of UOP <0.5 mL/kg/h) oliguria
Combes 2015 [13]	Unclassified	RRT initiation within 24 h post; cardiac surgery in shock requiring; high-dose catecholamine	Classic indication for RRT, life-threatening metabolic derangements

KDIGO= kidney disease: improving global outcomes, RRT= renal replacement therapy, Cr=creatinine, pre-op=preoperative, and UOP=urine output.
KDIGO 1: 1.5–1.9 times baseline or ⩾ 26.5 umol/L (0.3 mg/dl) increase in creatinine within 48 or UOP <0.5 ml/kg/h for 6–12 h.
KDIGO 2:2.0–2.9 times baseline increase in creatinine or UOP <0.5 ml/kg/h for > 12 h.
KDIGO 3: 3.0 times baseline or creatinine ⩾ 354 umol/L(4.0 mg/dl) or UPO <0.3 ml/kg/h for > 24 h or anuria for ⩾ 12 h.