A Prospective Evaluation of Two Rapid Phenotypical Antimicrobial Susceptibility Technologies for the Diagnostic Stewardship of Sepsis

Table 5

Antimicrobial susceptibility testing results of Alfred 60AST system compared to the routine SensiTitre system. Data are numbers (with percentages) of bacterial isolates for which the AST was performed. The summary of discrepancies as well as the AST agreement is reported in brackets.

(a)

Antimicrobial agent	Number of very major errors (%)	Number of major errors (%)	Number of minor errors (%)	AST agreement (%)	Total
Gram-positives
Ampicillin	0/3	0/2	0/5	5/5 (100.0)	5
Daptomycin	0/0	0/8	0/8	8/8 (100.0)	8
Linezolid	0/0	1/10 (10.0)	0/10	9/10 (90.0)	10
Vancomycin	0/1	2/6 (33.3)	0/7	5/7 (71.4)	7
Teicoplanin	0/1	4/8 (50.0)	0/9	5/9 (55.6)	9
Cefoxitin	0/1	0/3	0/4	4/4 (100.0)	4
Clindamycin	0/0	0/4	0/4	4/4 (100.0)	4
Total	0/6	7/41 (17.1)	0/47	40/47 (85.1)	47

(b)

Antimicrobial agent	Number of very major errors (%)	Number of major errors (%)	Number of minor errors (%)	AST agreement (%)	Total
Gram-negatives
Piperacillin/tazobactam	0/15	7/26 (26.9)	3/44 (6.8)	34/44 (77.3)	44
Ceftazidime	2/14 (14.3)	0/30	2/46 (4.4)	42/46 (91.3)	46
Cefotaxime	1/14 (7.1)	0/31	0/45	44/45 (97.8)	45
Meropenem	0/8	2/38 (5.3)	0/46	44/46 (95.7)	46
Gentamicin	4/8 (50.0)	1/37 (2.7)	0/45	40/45 (88.9)	45
Colistin	2/6 (33.3)	0/37	0/43	41/43 (95.4)	43
Levofloxacin	5/20 (25.0)	0/24	0/44	39/44 (88.6)	44
Trimethoprim-sulfamethoxazole	2/18 (11.1)	1/23 (4.4)	0/41	38/41 (92.7)	41
Cefuroxime	0/1	0/3	0/4	4/4 (100.0)
Total	16/104 (15.4)	11/249 (4.4)	5/358 (1.4)	326/358 (91.1)	358