Long-Term In Vivo Evaluation of Chitosan Nerve Guide Properties with respect to Two Different Sterilization Methods

Figure 1

Electrodiagnostic recordings depicting functional motor recovery at 16, 36, 56, and 76 weeks after surgery. Evoked compound action muscle potentials (CMAPs) were recorded from the anterior tibial (TA; (a), (c), (e)) and plantar muscles (PL; (b), (d), (f)) to evaluate amplitude ratios (a, b), axon loss (c, d), and nerve conduction velocity (NCV) ratios (e, f). Both groups, i.e., EO and β (both: n=24 at 16 weeks, n=18 at 36 weeks; EO: n=11 at 56 weeks, n=3 at 76 weeks; β: n=12 at 56 weeks, n=6 at 76 weeks) improved over time without significant differences between the groups. Two-way ANOVA followed by Tukey’s multiple comparison was used for statistical analysis of the results (p<0.05, p<0.01 versus 16 weeks within the same group; <0.05 versus 36 weeks within the same group). Results are displayed as medianrange.

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