Time-Dependent Effects of POT1 Knockdown on Proliferation, Tumorigenicity, and HDACi Response of SK-OV3 Ovarian Cancer Cells

Figure 4

Medium-term effect POT1-KD SK-OV3 cells displayed increased cell proliferation and more severe tumorigenicity than negative control cells. As shown in the cPD experiments, the cPDs of the negative control cells are depicted with black dots and lines, while the cPDs of the medium-term effect POT1-KD cells are depicted with black squares and lines (a). Images of the negative control and the medium-term effect POT1-KD cells were captured via digital phase-contrast microscopy at 4x magnification; scale bar: 1000 μm. The dark dots represent the colonies in soft agar (b). , compared with negative control cells.

(a)

(b)