Time-Dependent Effects of POT1 Knockdown on Proliferation, Tumorigenicity, and HDACi Response of SK-OV3 Ovarian Cancer Cells

Figure 5

POT1 mRNA expression was reduced, whereas c-Myc mRNA expression was increased in the medium-term effect POT1-KD cells, and as a result of the increase in c-Myc, hTERT mRNA expression was upregulated, telomerase activity was increased, and telomeres were elongated in the medium-term effect POT1-KD cells. The mRNA expression levels of POT1, c-Myc, and hTERT in the medium-term effect POT1-KD cells and negative control cells (a); the relative telomerase activity levels in the medium-term effect POT1-KD cells and negative control cells (b); and the relative telomere lengths in the medium-term effect POT1-KD cells and negative control cells (c). , compared with negative control cells.

(a)

(b)

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