Protective Role of Coxsackie-Adenovirus Receptor in the Pathogenesis of Inflammatory Bowel Diseases

Figure 5

Effect of CAR overexpression on DSS induced IBD development. (a) Bodyweight of different treatment groups during establishment of DSS induced IBD rat model. Day 0–day 7 indicates time frame for control/DSS containing water treatment. (b) Disease activity index (DAI) of different treatment groups. DAI was calculated as the sum of bodyweight loss score, fecal texture score, and fecal blood content score collected at the end of the study. (c & d) Colon length of different treatment groups at the end of the study. (e) H&E staining of colon tissue. (f) Expression of CAR was determined by qPCR. Colon tissue samples were collected after animals were treated with control or DSS/DSS+CAR, mRNA was isolated, and genes were detected by specific primers. , , and ; data represent mean ± s.e.m. from 3 independent experiments with sample size = 3 for each group.

(a)

(b)

(c)

(d)

(e)

(f)