Effect of Repeated Injection of Iodixanol on Renal Function in Healthy Wistar Rats Using Functional MRI
Table 3
ADC values changes in the 4 renal regions in Group 2 (×10−5 mm2/s).
Kidney tissue
Treatment
Baseline
1 h
1 d
3 d
5 d
10 d
CO
1-day subgroup
235 ± 10
195 ± 14
214 ± 17
222 ± 10
225 ± 12
229 ± 8
3-day subgroup
236 ± 8
201 ± 17
217 ± 15
225 ± 13
230 ± 14
232 ± 11
5-day subgroup
237 ± 8
204 ± 12
221 ± 15
231 ± 8
233 ± 9
240 ± 6
OSOM
1-day subgroup
229 ± 8
187 ± 11
216 ± 17
221 ± 11
227 ± 10
233 ± 7
3-day subgroup
231 ± 9
196 ± 11
222 ± 14
225 ± 7
232 ± 5
233 ± 5
5-day subgroup
232 ± 11
206 ± 18
222 ± 18
226 ± 16
229 ± 15
231 ± 6
ISOM
1-day subgroup
208 ± 9
171 ± 17
187 ± 19
191 ± 19
198 ± 18
202 ± 5
3-day subgroup
206 ± 10
178 ± 12
191 ± 16
201 ± 12
206 ± 11
212 ± 6
5-day subgroup
208 ± 8
183 ± 17
195 ± 13
203 ± 12
208 ± 11
210 ± 10
IM
1-day subgroup
238 ± 9
166 ± 11
227 ± 19
230 ± 14
234 ± 6
236 ± 10
3-day subgroup
236 ± 7
171 ± 13
229 ± 13
230 ± 15
236 ± 5
236 ± 6
5-day subgroup
238 ± 8
182 ± 15
230 ± 15
234 ± 6
236 ± 4
237 ± 9
DWI measurements were performed at baseline and 1 h, 1 day, 3 days, 5 days, and 10 days after the second injection, and mean ADC of each region of interest was measured. versus baseline.
