Possible Enzymatic Downregulation of the Natriuretic Peptide System in Patients with Reduced Systolic Function and Heart Failure: A Pilot Study

Figure 1

Corin, neprilysin, BNP, ANP, and cGMP levels in patients with normal (nEF) and reduced (rEF) ejection fractions, with and without decompensated (d) HF. (a) Corin and neprilysin plasma levels (mean±SE) in patient groups by corresponding HF score (mean±SE). (b) BNP levels (mean±SE) in groups with nEF (control), rEF, and rEF+ dHF according to HF score, where dHF is defined by a HF score ≥ 2 [10]. (c) ANP and cGMP plasma levels (mean±SD) in patient groups by HF score (mean±SE). N= 48, 16 per group. < 0.001, one-way ANOVA.

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