Possible Enzymatic Downregulation of the Natriuretic Peptide System in Patients with Reduced Systolic Function and Heart Failure: A Pilot Study

Table 2

Laboratory results.

Laboratory Test	Normal Systolic Function	Reduced Systolic Function (Systolic Dysfunction)
	Control	No Heart Failure	Heart Failure
BUN (mg/dL)	16 ± 5	19 ± 6	22 ± 9^§
Creatinine (mg/dL)	1.0 ± 0.2	1.1 ± 0.2	1.1 ± 0.2
eGFR (mL/min/1.73m^2)	92 ± 22	78 ± 19	89 ± 29
Sodium (mEq/L)	140 ± 3	139 ± 4	138 ± 4
Chloride (mEq/L)	103 ± 4	102 ± 3	101 ± 5
Bicarbonate (mEq/L)	27 ± 4	29 ± 4	28 ± 5
Leukocytes (x10^3/mm^3)	5.8 ± 1.3	7.0 ± 2.2	7.4 ± 3.1
Hemoglobin (g/dL)	12.5 ± 1.5	12.7 ± 1.3	12.1 ± 1.8
Hematocrit (%)	37 ± 5	38 ± 4	38 ± 5
Triglycerides (mg/dL)	139 ± 54	173 ± 79	95 ± 46^†
Total Cholesterol (mg/dL)	169 ± 32	154 ± 43	128 ± 37^§
HDL (mg/dL)	41 ± 21	38 ± 8	33 ± 14
LDL (mg/dL)	101 ± 28	82 ± 40	78 ± 29
AST (U/L)	45 ± 40	38 ± 12	50± 23
ALT (U/L)	38 ± 22	33 ± 15	37 ± 19
Alkaline Phosphatase (U/L)	94 ± 41	89 ± 21	130 ± 56^†
Total Bilirubin (mg/dL)	0.6 ± 0.7	0.6 ± 0.4	1.3 ± 0.8^§,†
Albumin (g/dL)	3.9 ± 0.5	4.2 ± 0.3	3.6 ± 0.6^†

p<0.05; ^§rEF + HF versus control, ^†rEF + HF versus rEF, and ^‡ rEF versus control. Data represent means ± SD unless otherwise indicated.