Possible Enzymatic Downregulation of the Natriuretic Peptide System in Patients with Reduced Systolic Function and Heart Failure: A Pilot Study

Table 3

Echocardiography parameters.

Laboratory Test	Normal Systolic Function (nEF)	Reduced Systolic Function (rEF)
	Control	No Heart Failure	Heart Failure
LVIDs, cm	3.3 ± 0.8	5.4 ± 1.2^‡	5.4 ± 0.9^§
LVIDd, cm	4.8 ± 0.8	6.2 ± 1.0^‡	6.2 ± 0.7^§
Left Atrium, cm	3.8 ± 0.4	3.9 ± 1.1	4.3 ± 0.5^§
Ejection Fraction, %	63 ± 3	27 ± 7^‡	24 ± 8^§
IVSd, cm	1.1 ± 0.2	1.0 ± 0.2	1.0 ± 0.3
AoRoot, cm	3.7 ± 0.3	3.4 ± 0.4	3.3 ± 0.5^§
LVOT, cm	2.0 ± 0.1	1.9 ± 0.1	2.1 ± 0.1^†
LVPWd, cm	1.1 ± 0.2	1.0 ± 0.1	1.0 ± 0.3
FS, %	32.7 ± 7.9	14.9 ± 6.0^‡	13.4 ± 6.3^§
LVM, g	225 ± 82	343 ± 213	290 ± 180
RVSP, mmHg	26 ± 10	37 ± 7^‡	44 ± 4^§
RVWM Abnormality N, (%)	0 (0)	7 (58)^‡	5 (36)^§
LVWM Abnormality N, (%)	0 (0)	9 (75^‡	11 (79)^§
RV Size Abnormal N, (%)	0 (0)	4 (25)	9 (60)^§
RV Function Abnormal N, (%)	15 (100)	11 (73)	3 (10)^§,†
Mitral Regurgitation N, (%)	1 (7)	2 (13)	9 (56)^§,†
Tricuspid Regurgitation N, (%)	0 (0)	2 (13)	12 (75)^§,†
Aortic Regurgitation N, (%)	0 (0)	0 (0)	4 (25)

p<0.05; ^§rEF + dHF versus control, ^†rEF + dHF versus rEF, and ^‡ rEF versus control. Data represent means ± SD unless otherwise indicated.