CT Myocardial Perfusion Imaging: A New Frontier in Cardiac Imaging

Table 2

Static single-energy CTP imaging.

Author; (Year)	Patients No.	CT Scanner	CTP Protocol	Stress Agent; (dose)	Analysis	Reference Standard	SE (%)	SP (%)	PPV (%)	NPV (%)	Average CT Dose
Blankstein et al [42]; (2009)	34	DS (1st)		Adenosine; (0.14 mg/kg/min)	Visual	SPECT; (for vessel)	84	80	71	90	9.1; mSv
Rocha-Filho et al [43]; (2010)	35	DS (1st)		Adenosine; (0.14 mg/kg/min)	Visual	QCA; (for vessel)	91	91	86	93	9.8; mSv
Feuchtner et al [46]; (2011)	30	DS (2nd)		Adenosine; (0.14 mg/kg/min)	Visual	MRI 1.5 T; (for vessel)	96	88	93	94	0.93; mSv
Cury et al [56]; (2011)	26	64-slice		Dypiridamole; (0.56 mg/Kg)	Visual	SPECT; (for patient)	94	78	89	87	14.4; mSv
Ko et al [57]; (2012)	40	320-slice		Adenosine; (0.14 mg/kg/min)	TPR; Visual^§	FFR; (for vessel); FFR; (for vessel)	74; 87	66; 95	56; 89	81; 94	4.5; mSv
George et al [44]; (2012)	50	320-slice		Adenosine; (0.14 mg/kg/min)	TPR	SPECT; (for patient)	72	91	81	85	7.0; mSv
Nasis et al [45]; (2013)	20	320-slice		Adenosine; (0.14 mg/kg/min)	Visual^§	QCA + SPECT; (for patient)	94	98	94	98	4.8; mSv
Bettencourt et al [58]; (2013)	101	64-slice		Adenosine; (0.14 mg/kg/min)	Visual^§	FFR; (for patient); MRI 1.5 T; (for patient)	89; 67	83; 95	80; 91	90; 78	5.0; mSv
Wong et al [59]; (2014)	75	320-slice		Adenosine; (0.14 mg/kg/min)	Visual + TAG^§	FFR; (for vessel)	97	84	76	98	4.8; mSv
Rochitte et al (CORE320 study) [60]; (2014)	381	320-slice		Adenosine; (0.14 mg/kg/min)	Semiq	QCA + SPECT; (for patient)	80	74	65	86	5.31; mSv
George et al (CORE320 study) [61]; (2015)	381	320-slice		Adenosine; (0.14 mg/kg/min)	Semiq	QCA; (for patient)	88	55	75	75	NA
Yang et al [62]; (2015)	75	DS (2nd)		Adenosine; (0.14 mg/kg/min)	Visual	FFR; (for patient); FFR; (for vessel)	89; 80	86; 95	96; 92	63; 87	6.5; mSv
Magalhaes et al (CORE320 study) [63]; (2015)	381	320-slice		Adenosine; (0.14 mg/kg/min)	Visual^§	QCA + SPECT; (for patient)	78	73	64	85	NA
Cury et al (Regadenoson crossover study) [64]; (2015)	110	Multivendor		Regadenoson; (0.4mg)	Semiq	SPECT	90	82	53	97	17.7; mSv

CTP, computed tomography perfusion; 1st and 2nd, first and second generation; CT, computed tomography; DS, Dual-Source scanner; FFR, fractional flow reserve; MRI, magnetic resonance imaging; PROSP, prospective ECG-gating acquisition; RETROSP, retrospective ECG-gating acquisition; NA, nonassessable; NPV, negative predictive value; PPV, positive predictive value; QCA, quantitative coronary angiography; SE, sensitivity; SP, specificity; Semiq, semiquantitative analysis using a stress score; SPECT, myocardial perfusion scan; TPR, transmural perfusion ratio; TAG, transluminal attenuation gradient; , global radiation dose of the stress-rest protocol; §, accuracy of CT perfusion integrated with the coronary anatomic data.