Review Article
Association between HLA-DP Gene Polymorphisms and Cervical Cancer Risk: A Meta-Analysis
Table 2
Meta-analysis of associations between HLA-DP alleles and cervical cancer.
| | Alleles | No. of studies | Case (2n) | Control (2n) | Heterogeneity P value | I2 value (%) for heterogeneity test | Model | OR (95%CI) | P value | Z | P value for Egger’s (Begg’s) bias test |
| | DPB102:01 | 6 | 743/5916 | 1397/10888 | 0.006 | 69.1 | R | 0.915 (0.741-1.130) | 0.409 | 0.82 | 0.981 (1.000) |
| | DPB102:02 | 4 | 103/1764 | 132/2300 | 0.071 | 57.4 | R | 1.261 (0.740-2.418) | 0.394 | 0.85 | 0.107 (0.089) |
| | DPB103:01 | 6 | 652/5878 | 1032/10888 | 0.080 | 49.1 | F | 1.252 (1.116-1.403) | 0.001 | 3.84 | 0.853 (1.000) |
| | DPB104:01 | 6 | 2015/5892 | 4215/10878 | 0.210 | 30.1 | F | 1.009 (0.932-1.092) | 0.821 | 0.23 | 0.240 (0.133) |
| | DPB104:02 | 4 | 412/4734 | 1075/9372 | 0.994 | 0.0 | F | 0.744 (0.652-0.848) | 0.001 | 4.41 | 0.781 (1.000) |
| | DPB105:01 | 5 | 744/3916 | 1031/3248 | 0.007 | 71.4 | R | 0.953 (0.728-1.248) | 0.727 | 0.35 | 0.129 (0.086) |
| | DPB113:01 | 5 | 177/3840 | 244/10166 | 0.015 | 67.7 | R | 1.518 (0.954-2.416) | 0.078 | 1.76 | 0.531 (0.806) |
| | rs4282438-T allele | 4 | 5309/10016 | 12197/18038 | 0.001 | 90.3 | R | 0.914 (0.688-1.213) | 0.533 | 0.62 | 0.382 (0.734) |
| | rs9277535 G allele | 4 | 4268/8266 | 4297/7402 | 0.509 | 0.0 | F | 0.802 (0.753-0.855) | 0.001 | 6.76 | 0.602 (1.000) |
| | rs3117027-G allele | 3 | 4994/7588 | 13159/18644 | 0.759 | 0.0 | F | 0.790 (0.745-0.837) | 0.001 | 7.92 | 0.055 (0.296) |
| | rs3077-C allele | 3 | 3494/5613 | 3374/5022 | 0.001 | 94.7 | R | 0.816 (0.560-1.189) | 0.290 | 1.06 | 0.957 (1.000) |
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The HLA-DP rs9277535 and rs3077 were just studied among Asian population.
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