Review Article
Association between HLA-DP Gene Polymorphisms and Cervical Cancer Risk: A Meta-Analysis
Table 4
Subgroup meta-analysis of associations between HLA-DP alleles and cervical cancer based on genotyping method.
| | Alleles | No. of studies | Genotyping
method | Case (2n) | Control (2n) | Heterogeneity P value | I2 value (%) for heterogeneity test | Model | OR (95%CI) | P value | Z | P value for Egger’s (Begg’s) bias test |
| | DPB102:01 | 5 | PCR | 506/3764 | 1263/9940 | 0.011 | 69.2 | R | 0.960 (0.749-1.231) | 0.750 | -0.24 | 0.996 (1.000) |
| | DPB103:01 | 5 | PCR | 372/3726 | 908/9940 | 0.355 | 9.0 | F | 1.354 (1.144-1.604) | 0.001 | 0.24 | 0.804 (0.806) |
| | DPB104:01 | 5 | PCR | 1068/3740 | 3798/9930 | 0.129 | 43.9 | F | 0.951 (0.748-1.210) | 0.685 | 1.71 | 0.319 (0.086) |
| | DPB104:02 | 3 | PCR | 218/2582 | 961/8424 | 0.989 | 0.0 | F | 0.750 (0.642-0.877) | 0.001 | 1.02 | 0.640 (1.000) |
| | DPB105:01 | 4 | PCR | 679/1764 | 1012/2300 | 0.034 | 65.4 | R | 0.874 (0.680-1.123) | 0.291 | 0.00 | 0.358 (0.308) |
| | rs4282438 | 2 | PCR | 2244/2496 | 8012/8470 | 0.159 | 49.6 | F | 0.842 (0.653-1.087) | 0.186 | 0.00 | - (1.000) |
| | Rs9277535 | 3 | TaqMan | 3666/7320 | 3370/6050 | 0.313 | 13.8 | F | 0.800 (0.740-0.865) | 0.001 | 0.00 | 0.695 (1.000) |
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