Dynamic Changes in Plasma MicroRNAs Have Potential Predictive Values in Monitoring Recurrence and Metastasis of Nasopharyngeal Carcinoma

Figure 1

Selection and validation of plasma miRNA in NPC patients. (a) Heat map of differentially expressed microRNAs from GeneSpring software between the NPC group () and the healthy control group (). Sixteen miRNAs were identified (). A vertical branch showed the expression pattern of candidate miRNAs in each individual. The relative expression was depicted according to the color scale shown in the figure. Red indicates upregulation and blue downregulation. Numbers with T indicate patients with NPC; numbers with C indicate healthy controls. (b) Validation of dysregulated miRNAs by qRT-PCR. An independent validation cohort included 102 patients with NPC and 35 healthy controls. Quantification was presented as mean values (error bars corresponded to standard deviation) relative to control from three independent experiments. and .

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