Screening Potential Probiotic Characteristics of Lactobacillus brevis Strains In Vitro and Intervention Effect on Type I Diabetes In Vivo

Table 6

Blood plasma assay (n=4, mean±SE).

	Ref. ranges	(Cont)	(STZ)	(INS+STZ)	(S1)	(S2)
	Plasma biochemical parameter
TG mmol/	0.45 -1.7	2.54±0.91	2.06±0.84	1.02±0.42	0.96±0.39	1.34±0.55
CHOL mmol/	2.85 – 5.7	7.25±	4.89±	3.38±	3.46±	3.44±
HDL mmol/	0.93 – 1.81	4.20±	1.55±	2.26±	2.39±	2.22±
LDL mmol/	2.07 – 3.63	1.14±	0.83±	0.49±	0.38±	0.48±
Mg^+2 mmol/	0.7-1.1	1.50±0.08	1.75±0.71	1.48±0.60	1.64±0.67	1.64±0.67
GLU mmol/	3.57 – 6.12	4.4±	4.40±	9.4±	3.1±	5.1±
Liver functions parameters
TP g/L	60.0-80.0	60.30±0.90	84.90±34.66	58.10±23.72	60.90±24.86	64.90±26.50
ALT IU/L	1.0 - 40.0	128.00±0.82	95.00±38.78	77.00±31.44	83.00±33.88	36.00±14.70
AST IU/L	1.0 - 40.0	263.00±0.82	341.00±139.21	176.00±71.85	274.00±111.86	182.00±74.30
AST/		2.05±	3.59±	2.29±	3.30±	2.89±
TBA mol/	0.01-20.0	8.50±0.90	4.90±2.00	3.90±1.59	2.60±1.06	3.90±1.59
ALB g/L	35.0-55.0	34.50±	39.10±	33.70±	36.50±	37.50±
GLUB g/L	25.0-40.0	25.80±0.90	45.80±18.70	24.40±9.96	24.40±9.96	27.40±11.19
A/	1.5 -2.5	1.34±	0.85±	1.38±	1.50±	1.37±
Kidney function parameter
BUN mmol/L	1.07 – 7.14	8.60±3.51	10.50±4.29	8.00±3.27	11.80±4.82	10.80±4.41
CREA mol/L	53.0 – 132.0	44.30±18.09	40.50±16.53	39.10±15.96	37.40±15.27	41.90±17.11
URIC Umol/	142.0 –401.0	76.50±	175.10±	180.60±	125.60±	164.90±
Insulin blood plasma
Insulin uIU/ml	3-19	13.52±0.23	9.99± 0.36	10.60±0.21	11.13±0.28	10.93±0.20

TG, triglyceride; CHOL, total cholesterol; HDL, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; GLU, glucose; Mg⁺², magnesium; ALT, serum alanine aminotransferase; AST, aspartate aminotransferase; AST/ALT, presence of aspartate transaminase and serum alanine aminotransferase; TBA, total bile acid; ALB, albumin; GLUB, globulin; TP, total protein; BUN, uric nitrogen; CREA, creatinine; URIC, uric acid. (Cont), control; (STZ), streptozotocin; (INS+STZ), insulin; (S1), KLDS 1.0727; (S2), KLDS 1.0373.