Drosophila as a Model System to Study Cell Signaling in Organ Regeneration

Figure 2

Signaling network promoting apoptosis and Ros production after discs damage. Damage causes the activation of different signals that lead to apoptosis and high levels of Ros accumulation in dying cells. The function of Duox leads to extracellular Ros production that is responsible for hemocyte recruitment and promotes the activation of different signaling pathways in surrounding cells. Hemocytes secrete Eiger, which activates JNK pathway in the adjacent cells. Apoptotic cells produce also different signals that influence surrounding cells.