Comparative Proteomic Study of the Antiproliferative Activity of Frog Host-Defence Peptide Caerin 1.9 and Its Additive Effect with Caerin 1.1 on TC-1 Cells Transformed with HPV16 E6 and E7

Figure 4

IPA identified “Tec kinase family signalling” as the canonical pathway in the cells with the highest predicted potential/significance of being affected by the treatment of caerin 1.9, based on iTRAQ data. The up/downregulations of proteins induced by caerin 1.9 are indicated by nodes with range of red and green intensities. The activation or inhibition of certain signalling was shown in orange or blue, respectively. Lines connecting the proteins represent known interactions, and arrows indicate the directions of up/downstream regulations.