Antidepressant-Like and Neuroprotective Effects of Ethanol Extract from the Root Bark of Hibiscus syriacus L.

Figure 2

Effects of HSR on depression-related behaviors in restraint stress-induced mice. (a) Animal experimental protocol. The mice were orally administered vehicle (saline), HSR (100, 200, or 400 mg/kg), or fluoxetine (FXT; 20 mg/kg) daily for the indicated period. Restraint stress and oral administration schedules for behavioral experiments are presented. FST: forced swimming test; SPT: sucrose preference test; TST: tail suspension test. (b) Sucrose preference was measured on the indicated days. The immobility time in (c) FST and (d) TST was measured on day 23. Data are the mean ± SD (n = 6). p < 0.05, p < 0.01, and p < 0.0001 vs. the normal group; p < 0.05, p < 0.01, p < 0.001, and p < 0.0001 vs. the control group.

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