Antidepressant-Like and Neuroprotective Effects of Ethanol Extract from the Root Bark of Hibiscus syriacus L.

Figure 4

Effects of HSR on BDNF and p-CREB/CREB expression in the brain of restraint stress-induced mice. Lysates of isolated prefrontal cortex and hippocampus were analyzed by western blotting using (a) BDNF and (b) p-CREB/CREB antibodies. β-Actin was used as the loading control. The data are representative of three independent experiments. Data are the mean ± SD (n = 3). p < 0.001 vs. the normal group; p < 0.05, p < 0.01, p < 0.001, and p < 0.0001 vs. the control group.

(a)

(b)