miR-548b-3p Regulates Proliferation, Apoptosis, and Mitochondrial Function by Targeting CIP2A in Hepatocellular Carcinoma

<div><b>miR-548b-3p targets and downregulates CIP2A.</b> (a) Western blot demonstrated that miR-548b-3p mimic decreased CIP2A and c-myc expression while upregulating cleaved PARP in Huh7 cells. miR-548b-3p inhibitor showed the opposite effect in SK-Hep-1 cells. (b) miR-548b-3p mimic suppressed the luciferase activity of wild-type reporter, while no significant change was observed in that of the mutant reporter.</div>

BioMed Research International

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Figure 4

Figure 4: miR-548b-3p Regulates Proliferation, Apoptosis, and Mitochondrial Function by Targeting CIP2A in Hepatocellular Carcinoma 