A Comparative Study for Detection of EGFR Mutations in Plasma Cell-Free DNA in Korean Clinical Diagnostic Laboratories

Figure 1

Analytical sensitivity of the cobas EGFR assay for NHP spiked with five different levels of mutant cfDNA. Copy numbers and frequencies of mutant alleles are provided in Supplementary Table . Dots in the figure represent negative measurement (ND) or the SQI value of the positive measurement for (a) p.E746_A750del (exon 19 deletion), (b) p.L858R, (c) p.T790M, and (d) p.A767_V769dup (exon 20 insertion) mutations.

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