Genetic Polymorphism in the RYR1 C6487T Is Associated with Severity of Hypospadias in Chinese Han Children

Figure 3

Genotype and allele frequency distribution of C6487T polymorphism of RYR1 gene between the case and control groups. The frequency distribution of CT, TT, and CT + TT genotypes of RYR1 C6487T polymorphism between the case and control groups exhibited significant differences, as well as the frequency distribution of T allele (CT versus CC: OR = 1.750, P = 0.002, and 95% CI = 1.223-2.505; TT versus CC: OR = 2.689, P = 0.001; CT + TT versus CC: OR = 1.905, P = 0.002, and 95% CI = 1.445-5.006; T versus C: OR = 1.773, P < 0.001, and 95% CI = 1.356-2.319) (all P < 0.05).

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