The Role of Wnt Pathway in the Pathogenesis of OA and Its Potential Therapeutic Implications in the Field of Regenerative Medicine

Table 2

In vitro human studies included.

Reference	Author	Subjects	Pathway involved	Results
[5]	J. Wu et al. (2017)	Human chondrocytes from OA (n=57) and healthy subjects (n=6) knees	SOST/Wnt	SOST may not have beneficial effects on chondrocytes affected by OA
[9]	F. Dell’Accio et al. (2008)	human articular chondrocytes (explants 24 hours after mechanical injury) from 8 patients	Wnt family	A systematic analysis of the Wnt signalling pathway revealed up-regulation of Wnt-16, down-regulation of FRZB, up-regulation of Wnt target genes, and nuclear localization of beta-catenin in injured cartilage
[13]	S.-G. Gao et al. (2016)	40 patients with various stages of primary OA cartilage and subchondral bone from tibial plateau	WIF-1	Patients with disease had significantly decreased WIF-1 levels. Thus, WIF-1 levels were negatively correlated with the severity of the disease