C57BL/6 transgenic mice and OA human (n=10) articular chondrocytes
EZH2
EZH2 level was found significantly increased. Pharmacological inhibition of EZH2 silenced β-catenin signalling pathway and delayed OA progression in mice
Overexpressing Dkk-1 by intra-articular injection significantly reduced progression of OA in mice induced with DMM thanks to the inhibition of Wnt-mediated expression of catabolic factors
Cell culture of bone-marrow-derived human mesenchymal stem cells (hMSCs) and in vivo studies in a rodent acute cruciate ligament tear and partial medial meniscectomy (ACLT + pMMx) OA model
SM04690
SM04690 induced hMSC differentiation into mature, functional chondrocytes and decreased cartilage catabolic marker levels compared to vehicle. A single SM04690 intra-articular (IA) injection was effective in a rodent OA model