BioMed Research International / 2018 / Article / Tab 2

Research Article

Antimicrobial Potential of Caffeic Acid against Staphylococcus aureus Clinical Strains

Table 2

Antibacterial potential of caffeic acid (CA) alone and in antibiotic-phytochemical combination against Staphylococcus aureus. The combined effect of CA and antibiotics was evaluated using plates with MHA enriched with the subinhibitory concentration of CA.

C MI (µg/mL)E+CADDA+CA-Δ%FOFOX+CA-Δ%VVA+CA-Δ%

S. aureus ATCC 259232560.380.3800.0640.047-271100.750.750
S. aureus ATCC 4330025625625602562560128-330.380.50-32
S. aureus ATCC 65382560.0640.125950.023<0.016-3021-500.500.500
S. aureus 110240.500.25-500.0640.032-5021.5-250.750.50-33
S. aureus 25120.500.38-240.0640.06400.750.7500.380.7597
S. aureus 35122560.19<-99.990.023<0.016-301.50.38-750.500.500
S. aureus 45120.380.19-500.0640.047-2721-500.500.500
S. aureus 55122564-980.0940.064-3225624-910.750.50-33
S. aureus 65120.500.125-750.064<0.016-751.51.500.380.5032
S. aureus 72560.380.19-500.0320.03201100.500.38-24
S. aureus 810240.190.1900.032<0.016-501.50.50-670.380.380
S. aureus 95120.380.19-500.064<0.016-751100.380.380
S. aureus 10512323-910.047<0.016-6620.75-630.380.380
S. aureus 1110240.380.19-500.0470.032-321.50.75-500.380.19-50
S. aureus 125122562560256256025625600.750.750
S. aureus 135122560.125<-99.992560.094<-99.993212-630.750.50-33
S. aureus 141024256<0.016<-99.99256<0.016<-99.99256<0.016<-99.990.75<0.016-98
S. aureus 1510240.250.19-240.0640.023-6481.5-810.380.380
S. aureus 1610242562560256256025632-880.500.500
S. aureus 17512256<0.016<-99.99256<0.016<-99.99256<0.016<-99.990.38<0.016-96
S. aureus 185120.380.094-750.047<0.016-6660.75-880.500.500
S. aureus 1910242562560256256025664-750.500.500
S. aureus 20256256<0.016<-99.99256<0.016<-99.9912<0.016<-99.990.38<0.016-96
Median5120.50.19-500.0640.032-3221-630.500.50
pi0.00040.00030.00030.091

taphylococcus aureus 1 ÷ 20: strains from intractable surgical wounds.
: caffeic acid.
: minimum inhibitory concentration.
: erythromycin.
ICs changes according to the formula [(MIC of antibiotic - MIC of antibiotic with CA) / MIC of antibiotic] x 100%.
A: clindamycin.
OX: cefoxitin.
A: vancomycin.
ilcoxon Signed-Rank Test.