Morphological Predictive Features on Spectral-Domain Optical Coherence Tomography for Visual Outcomes in Neovascular Age-Related Macular Degeneration Treated with Ranibizumab

Figure 3

The results of the multivariate correlational analysis of spectral-domain optical coherence tomography (SD-OCT) qualitative morphological features ((a) presence of pigment epithelial detachment (PED) > 250 μm, subretinal fluid, cystoid macular edema, subretinal hyperreflective exudation, hyperreflective dots, and alteration of the ellipsoid zone) and quantitative morphological features [(b) central retinal thickness (measured in μm) and (c) subfoveal choroidal thickness (SFCT, measured in μm)] between both “responders” and “nonresponders” groups. The presence of PED > 250 μm and SFCT was found to statistically affect the response to Ranibizumab injections (marked as ) in age-related macular degeneration patients (p-value was derived from analysis of variance for continuous variables and Monte Carlo exact tests for categorical analysis).

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